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Be aware: Non-pharmaceutical medical interventions can be as harmful as pharmaceutical ones

Be aware: Non-pharmaceutical medical interventions can be as harmful as pharmaceutical ones

I’m living proof of it!

Hedley Rees's avatar
Hedley Rees
Sep 02, 2024
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INSIDE PHARMA
INSIDE PHARMA
Be aware: Non-pharmaceutical medical interventions can be as harmful as pharmaceutical ones
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The story begins

The story goes back over twenty years, when I was working for a biotech company developing a triptan. Find out more on triptan’s here: Triptans.

In short, triptan’s are used for the treatment of acute migraine headache and associated effects. The drug acts as a vasoconstrictor, to help combat dilation of the blood vessels in the brain, the suggested cause of a migraine.

The technical details can be found here:

Mechanisms of action of the 5-HT1B/1D receptor agonists

This is an extract:

“Triptans are antimigraine agents that bind to 5-HT1B and 5-HT1D serotonin receptors. Triptan binding to the vascular 5-HT1B receptors leads to vasoconstriction of the cranial arteries, which dilate during a migraine attack. When triptans bind to the neurogenic and central 5-HT1D receptors, they prevent the release of vasoactive neuropeptides by inhibiting tri…

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