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THE COVID-19 SUPPLY CHAIN: Fact not Fiction - 5 Star rating from Simon Kershaw
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…was given a 5 Star rating by subscriber Simon Kershaw, this is it:
Top review from United Kingdom
(Review also on Amazon.com, here)
Reviewed in the United Kingdom on 28 August 2023
This book is fundamental knowledge!
To understand what we just did, it is necessary to get this level of education.
In review of this book I make this fundamental quote for you to understand it’s worth -
‘There are two types of drugs produced in pharma.
Small molecule something like aspirin a known risk reward
And Large molecule, ‘Biologics’
It is important to remember that biologics are an order of magnitude more challenging to produce than small molecule products
In biologics the molecules are so large and complex that is often impossible to define the molecular structures by analysis.
All that is known is that it is a particular process to produce something that has a particular biological effect on a patient.
Another manufacturer may not be able to replicate that product and its clinical effect even if the process appears to be the same.
The process IS the product.
This has major implications for the regulation of biological products as different manufacturers produce products that could be clinically different.
Only if studies are carried out to prove that different manufacturers produced those products and are interchangeable can one be substituted for the other.
Biologics are inherently less stable at room temperatures than small molecule products, the sensitivity of biologics to temperature variation and other environmental factors is immense, remember they are living things.’
This book sets out concisely why this is so and is well written to clearly explain what is an exceptionally complex subject that both scientist & layman can understand, so that we all can make more informed decisions next time.
Thanks Simon, and hope it’s the first on many!
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