CAR-T therapy and the mRNA vaccines have a conceptual similarity, that of using knowledge of genetics to eliminate or reduce disease. There is however a key difference. In the case of CAR-T therapy, the alterred T cells will remain in the patient, capable of producing altered T-cells to combat the cancer., however with the possibility of unintended/unforeseen consequences.
In the case of the mRNA vaccines, used to treat viral infection, it should be remembered that protein production uses 3 types of RNA , mRNA to say which protein to make, tRNA to transfer the amino acids to the ribosome and rRNA in the ribosome to make the protein required. mRNA is short lived and get broken down by enzymes back into its component ribonucelotides, which can be reassembled in a different sequence to make a different mRNA strand for any different protein which the cells need.
Alteration of human DNA through viral infection can happen with retroviruses, or the presence of reverse transcriptase. I have not seen any literature suggesting SARS COV-2 is a retrovirus, thus far.
Worrying that the GxP issues have not been adequately dealt with. Training records of all personnel involved at each stage should reflect qualifications, training and any pass/fail stages which require re-training etc to ensure there is adequate confidence that every stage of manufacture is carried out to the letter of the approval by personnel of proven capability and not stretched beyong that scope wihout PRIOR regulatory approval. As Hedley rightly emphasises, scale up has issues which need to be anticipated, examined and proven benign before human use. Normally animal studies would precede clinical studies, before seeking supplementary approval from the regulatory bodies.
An outstanding and highly informative interview, thank you for sharing this.
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Our Human Bodies Are Water Based.
Nothing Derived From Manufactured Metals Or Petroleum Should Be Injected Into Them.
Nothing. Not A Goddamn Particle.
Next Question ...
( There Shouldn’t Be Any. )
( And There Never Should Have. )
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Did the interview continue after 16 mins?
No - what else do you need to know Markker?
I think I was confused as she said "back in a minute" going to a commercial break, that's all! I'm sure you could have talked for hours more.
CAR-T therapy and the mRNA vaccines have a conceptual similarity, that of using knowledge of genetics to eliminate or reduce disease. There is however a key difference. In the case of CAR-T therapy, the alterred T cells will remain in the patient, capable of producing altered T-cells to combat the cancer., however with the possibility of unintended/unforeseen consequences.
In the case of the mRNA vaccines, used to treat viral infection, it should be remembered that protein production uses 3 types of RNA , mRNA to say which protein to make, tRNA to transfer the amino acids to the ribosome and rRNA in the ribosome to make the protein required. mRNA is short lived and get broken down by enzymes back into its component ribonucelotides, which can be reassembled in a different sequence to make a different mRNA strand for any different protein which the cells need.
Alteration of human DNA through viral infection can happen with retroviruses, or the presence of reverse transcriptase. I have not seen any literature suggesting SARS COV-2 is a retrovirus, thus far.
Worrying that the GxP issues have not been adequately dealt with. Training records of all personnel involved at each stage should reflect qualifications, training and any pass/fail stages which require re-training etc to ensure there is adequate confidence that every stage of manufacture is carried out to the letter of the approval by personnel of proven capability and not stretched beyong that scope wihout PRIOR regulatory approval. As Hedley rightly emphasises, scale up has issues which need to be anticipated, examined and proven benign before human use. Normally animal studies would precede clinical studies, before seeking supplementary approval from the regulatory bodies.