I trust your assessment of the COVID scam. No wonder Bill Gates made money on the back of COVID, and had the neck to boast about it. I have lost what little faith I had in politicians and most doctors. The ones that stood out against the reset are to be admired. Thank you for this information
That means a lot Clare, knowing that you trust the information and value it. I aim to continue sharing what I know, in the hope that more people will “see the light” in this awful darkness of smoke and mirrors 👍😁🙏
just curious to get others opinions...maybe i am missing something.
has anyone looked at Starboard Value's presentation to pfizer's board of directors?
specifically slide 4 it shows a vaccine update chart + daily deaths from covid chart.
to me, it looks like this would be a chart i'd read on steve kirsch's substack because it shows 2 massive spikes in deaths after the shots rolled out.
i am uncertain where the narrative is on how safe & effective the covid shots were - but i thought it was: we never said it'd stop transmission nor infection, but it certainly stops severe illness & death.
and yet, starboardvalue presents this chart showing lots of death after 60%+ vaccine uptake...and werent healthcare providers & the elderly the first in line / group A? so they were all dosed by the time the less dangerous variants (delta & omicron) came on to the scene and yet - still 2 significant spikes in death.
the presentation can be found on twitter by simply searching for 'starboard', here is a link to it from the activist investor group's website:
I can't comment on the specifics, but what I would say about Pfizer's performance is this. In 2000, Pfizer paid $116Bn for Warner Lambert, to get its hands on the blockbuster statin Liptor, because it was facing patient cliff issues as no new products were coming through. In 2011, that Lipitor patent expired, and in anticipation, Pfizer bought Wyeth, for $68BN in 2009. Wyeth was a specialist biologics manufacturer, and most of the good, skilled people left because of the Pfizer culture. So, Pfizer was staying afloat by buying pipelines from other companies, and it never brought a biologic to market, until Comirnaty! Not just Pfizer, they all were - GSK, Novartis etc. I'm presenting this as further evidence that Big Pharma companies invented to COVID scam as last chance saloon - that's the honest truth, and you will begin to believe it if you stay with INSIDE PHARMA!!!
I’ve worked in the hedge fund world and you might find they’re more receptive than you think. Most will pay consultants who have specialist expertise or data that they can’t access elsewhere. They’re long of Pfizer stock and they’re running a public campaign to convince other investors to buy the stock. They also want to get representatives on the Pfizer board to force a change in strategy. Their report mentions Covid 57 times, but litigation, regulation and supply chain are mentioned zero times. These are huge risks that they have overlooked and you have the missing expertise. If they get this wrong their reputation will take a dive.
The cost of sending them an email is zero. There’s a chance they’ll respond, have an introductory call and then you can pitch a consultancy contract. The least you’ll get is a couple of book sales.
pfizer is notorious for buying companies for products (future revenues) and firing personnel.
it seems like they are in a fight for their life trying to slash $4 billion in costs in the near future while the seattle genetics among other recent acquisitions flounder…
seattle genetics had a $2 billion revenue stream when pfizer paid $40 billion for them!
Fascinating read - thanks for sharing that. 72 pages of criticism which seems valid followed by a conclusion “we are excited to own the business at current valuation multiples”. Are they nuts? Pfizer stock - it’s a dog with fleas as Gordon Gekko might say.
What do you know about manufacturing of biologics? Would it be possible to make LNPs encrusted with mRNA payloads with the same equipment used to make Monoclonal antibodies? 🤔
There is some idea/observations out there that point out that the Antibody Patent Paradox was unexpected (e.g. the ruling from SCOTUS that basically killed AB patents). This would've provided a bridge income source as the egg based vaccine patents expired and would've given them more years to produce mRNA "drugs".
Well Soothspider, I was a member of the UK bio-industry association's manufacturing advisory committee (BIA MAC) from 2007 - 2011, so I learned a lot then. I also consulted to Oxford BioMedica in 2013, a cell and gene therapy contract manufacturer, the company that developed the adenovirus injections for AZ, subsequently.
As you probably know, the 1st mAb to market was Genentech's Herceptin (Trastuzumab), approved in 1998. Genentech researchers employed a process called recombination, which consists of using proteins called restriction enzymes to cut bacterial DNA. The enzymes left uneven cuts on the DNA chain where foreign DNA could be inserted. The bacteria would then start using the new genetic information as if it were its own. More here: https://www.labiotech.eu/in-depth/history-biotechnology-genentech/
The manufacturing process is three stages:
1 produce cell-line (eg e-coli)
2 upstream processing (in cell factories or bioreactors)
3. downstream processing (fill bulk liquid into vials and seal)
The principles are the same for mAbs and gene modified cell therapy (SARS-CoV-2 injections, and the equipment is readily available to companies with the $$$ to purchase it).
As you mention, the patent issue for mAbs, along with the challenges in developing biosimilars (copies) that could be proven clinically equivalent to the originals, damped down the market.
Then, in 2014, FDA gave breakthrough designation to CAR T therapy (gene modified cell therapy), and that led to Novartis' Kymriah being approved August 2017. At $475,000 per treatment regimen, healthcare providers pushed back hard, and the side effect turned out to be nasty, see: https://www.fda.gov/media/107296/download CAR T had stalled; enter SARS-CoV-2 sterile injectables...
WARNING: CYTOKINE RELEASE SYNDROME, NEUROLOGICAL TOXICITIES, and SECONDARY HEMATOLOGICAL MALIGNANCIES
• Cytokine Release Syndrome (CRS), including fatal or life-threatening reactions, occurred in patients receiving KYMRIAH. Do not administer KYMRIAH to patients with active infection or inflammatory disorders. Treat severe or life-threatening CRS with tocilizumab or tocilizumab and corticosteroids [see Dosage and Administration (2.3, 2.4), Warnings and Precautions (5.1)].
• Neurological toxicities, which may be severe or life-threatening, can occur following treatment with KYMRIAH, including concurrently with CRS. Monitor for neurological events after treatment with KYMRIAH. Provide supportive care as needed [see Warnings and Precautions (5.2)].
• T cell malignancies have occurred following treatment of hematologic malignancies with BCMA- and CD19- directed genetically modified autologous T cell immunotherapies, including KYMRIAH [see Warnings and Precautions (5.9)].
• KYMRIAH is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the KYMRIAH REMS [see Warnings and Precautions (5.3)].
—-
It looks like the idea is to target the CD19 glycoprotein/receptor/co-receptor using modified T-Cells (CD8+’s?) to wipe out the population of B-cells (naive, memory, plasma) that express it. The main idea is that the CD19 receptor is highly specific to “cancerous” B-cells (lymphoma). Yet CD19 seems to actually play a role in B-Cell activation.
Seems like this strategy is akin to saying that inflammation is bad for you. Let’s kill all the cells that look inflamed.
It doesn’t seem like they have any appreciation for the complex signaling and orchestration that all these immune system cells do to keep everything from collapsing.
Anyhow, it’s interesting how all these biologics is basically supported by a number of key technology platforms that make them a bit interchangeable.
Regarding mABs, they are probably a much simpler therapeutic if one thinks about it. The “base” (and probably wrong) understanding is that ABs are a simple flagging mechanism for the immune system which will then target the attached organic. To make it extra good, they also target RBDs (Receptor Binding Domains) so that even if the immune system doesn’t do it’s job, it at least “blocks” the effect of the target organic.
Yet, when you look into well established mABs like Solensia(cats)/Librela(dogs) which target the NGF (nerve growth factor) and many groups popping up with names like “Solensia killed my cat”, it’s clear they don’t even know how ABs work in the system. Yet, hubris is going to lead them to believe they can inject even more complicated biologics into an incredibly complex system they barely understand have it "work”. 🤞🤞
I think your comment regarding everyone knowing about pharma's carrying on's is wrong, I certainly had no idea until the last few years and majority still have no idea, as they wave me away with my conspiracy facts! Hedley, I've been searching through your articles, with no luck, for the one that mentions the "international regulatory body" that advises individual regulatory bodies. Can you provide link please? Thanks.
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) is unique in bringing together the regulatory authorities and pharmaceutical industry to discuss scientific and technical aspects of pharmaceuticals and develop ICH guidelines. Since its inception in 1990, ICH has gradually evolved, to respond to increasingly global developments in the pharmaceutical sector and these ICH guidelines are applied by a growing number of regulatory authorities. ICH's mission is to achieve greater harmonisation worldwide to ensure that safe, effective and high quality medicines are developed, and registered and maintained in the most resource efficient manner whilst meeting high standards. Since its announcement of organisational changes in October 2015, ICH has grown as an organisation and now includes 23 Members and 35 Observers."
This is an NGO set up by WHO/Bill Gates in 2012: https://www.icmra.info/drupal/en/aboutus/icmra_chair Note the 1st Chair was CEO of MHRA,, who became a Gates Foundation employee in 2019, and the current chair Ms Emer Cooke, former WHO, now executive director of the European Medicines Agency!!!
Thanks. On Jonathan Engler's stack, he is looking to find out more on an international association of medical regulatory agencies. Look here sanityunleashed.substack.com/p/who-funds-controls-this-shadowy-umbrella Are they related/same? I watched the video a long time ago and wondered if anyone looking into it.
From what I can see, the IAMRA is different to the ICMRA. In terms for facilitating COVID, I'd say the ICMRA is the one with its tentacles around all the global, country based authorities. Take a look at the membership: https://www.icmra.info/drupal/en/aboutus/participatingregulatoryauthorities - ICMRA is duplicating the work of ICH, which was formally set up to be a global harmonization vehicle,
The ich.org has press release for June 2024 in Japan. Additional agenda item is Assessment and control of DNA Reactive (Mutagenic) impurities in pharmaceuticals to limit potential carcenogenic risk" horse - stable - door - bolted, springs to mind.
I trust your assessment of the COVID scam. No wonder Bill Gates made money on the back of COVID, and had the neck to boast about it. I have lost what little faith I had in politicians and most doctors. The ones that stood out against the reset are to be admired. Thank you for this information
That means a lot Clare, knowing that you trust the information and value it. I aim to continue sharing what I know, in the hope that more people will “see the light” in this awful darkness of smoke and mirrors 👍😁🙏
just curious to get others opinions...maybe i am missing something.
has anyone looked at Starboard Value's presentation to pfizer's board of directors?
specifically slide 4 it shows a vaccine update chart + daily deaths from covid chart.
to me, it looks like this would be a chart i'd read on steve kirsch's substack because it shows 2 massive spikes in deaths after the shots rolled out.
i am uncertain where the narrative is on how safe & effective the covid shots were - but i thought it was: we never said it'd stop transmission nor infection, but it certainly stops severe illness & death.
and yet, starboardvalue presents this chart showing lots of death after 60%+ vaccine uptake...and werent healthcare providers & the elderly the first in line / group A? so they were all dosed by the time the less dangerous variants (delta & omicron) came on to the scene and yet - still 2 significant spikes in death.
the presentation can be found on twitter by simply searching for 'starboard', here is a link to it from the activist investor group's website:
https://www.starboardvalue.com/wp-content/uploads/2024_Active-Passive_Investor_Summit_-_Pfizer_Inc.pdf?utm_campaign=the_readout&utm_medium=email&_hsenc=p2ANqtz-8IXutMnNdt9eR1LVMOw6hsluiwiWLxXBR29djf_OQk-lxlVohImrjmlZCQS4hnVe8pHBNnSaXQ3Ax2oJYo1YBR1orm8Q&_hsmi=330436220&utm_content=330436220&utm_source=hs_email
I can't comment on the specifics, but what I would say about Pfizer's performance is this. In 2000, Pfizer paid $116Bn for Warner Lambert, to get its hands on the blockbuster statin Liptor, because it was facing patient cliff issues as no new products were coming through. In 2011, that Lipitor patent expired, and in anticipation, Pfizer bought Wyeth, for $68BN in 2009. Wyeth was a specialist biologics manufacturer, and most of the good, skilled people left because of the Pfizer culture. So, Pfizer was staying afloat by buying pipelines from other companies, and it never brought a biologic to market, until Comirnaty! Not just Pfizer, they all were - GSK, Novartis etc. I'm presenting this as further evidence that Big Pharma companies invented to COVID scam as last chance saloon - that's the honest truth, and you will begin to believe it if you stay with INSIDE PHARMA!!!
Starboard is an activist investor. They claim to make profits from over 80% of their campaigns. Maybe you should offer your services Hedley.
https://www.starboardvalue.com/contact/
They would need to recognise the value in speaking to me, Alan, and of course, they wouldn't. I feel sorry for any investors that are listening to them. I fact, I feel sorry for anyone investing in today's big pharma smoke and mirrors - the bubble is set to burst. You might check this out: https://open.substack.com/pub/hedleyrees/p/why-biotech-gene-therapy-investors?r=xoehy&utm_campaign=post&utm_medium=web
I’ve worked in the hedge fund world and you might find they’re more receptive than you think. Most will pay consultants who have specialist expertise or data that they can’t access elsewhere. They’re long of Pfizer stock and they’re running a public campaign to convince other investors to buy the stock. They also want to get representatives on the Pfizer board to force a change in strategy. Their report mentions Covid 57 times, but litigation, regulation and supply chain are mentioned zero times. These are huge risks that they have overlooked and you have the missing expertise. If they get this wrong their reputation will take a dive.
The cost of sending them an email is zero. There’s a chance they’ll respond, have an introductory call and then you can pitch a consultancy contract. The least you’ll get is a couple of book sales.
pfizer is notorious for buying companies for products (future revenues) and firing personnel.
it seems like they are in a fight for their life trying to slash $4 billion in costs in the near future while the seattle genetics among other recent acquisitions flounder…
seattle genetics had a $2 billion revenue stream when pfizer paid $40 billion for them!
Great comment, thanks 👍🙏
Fascinating read - thanks for sharing that. 72 pages of criticism which seems valid followed by a conclusion “we are excited to own the business at current valuation multiples”. Are they nuts? Pfizer stock - it’s a dog with fleas as Gordon Gekko might say.
What do you know about manufacturing of biologics? Would it be possible to make LNPs encrusted with mRNA payloads with the same equipment used to make Monoclonal antibodies? 🤔
There is some idea/observations out there that point out that the Antibody Patent Paradox was unexpected (e.g. the ruling from SCOTUS that basically killed AB patents). This would've provided a bridge income source as the egg based vaccine patents expired and would've given them more years to produce mRNA "drugs".
Thoughts?
Well Soothspider, I was a member of the UK bio-industry association's manufacturing advisory committee (BIA MAC) from 2007 - 2011, so I learned a lot then. I also consulted to Oxford BioMedica in 2013, a cell and gene therapy contract manufacturer, the company that developed the adenovirus injections for AZ, subsequently.
As you probably know, the 1st mAb to market was Genentech's Herceptin (Trastuzumab), approved in 1998. Genentech researchers employed a process called recombination, which consists of using proteins called restriction enzymes to cut bacterial DNA. The enzymes left uneven cuts on the DNA chain where foreign DNA could be inserted. The bacteria would then start using the new genetic information as if it were its own. More here: https://www.labiotech.eu/in-depth/history-biotechnology-genentech/
The manufacturing process is three stages:
1 produce cell-line (eg e-coli)
2 upstream processing (in cell factories or bioreactors)
3. downstream processing (fill bulk liquid into vials and seal)
The principles are the same for mAbs and gene modified cell therapy (SARS-CoV-2 injections, and the equipment is readily available to companies with the $$$ to purchase it).
As you mention, the patent issue for mAbs, along with the challenges in developing biosimilars (copies) that could be proven clinically equivalent to the originals, damped down the market.
Then, in 2014, FDA gave breakthrough designation to CAR T therapy (gene modified cell therapy), and that led to Novartis' Kymriah being approved August 2017. At $475,000 per treatment regimen, healthcare providers pushed back hard, and the side effect turned out to be nasty, see: https://www.fda.gov/media/107296/download CAR T had stalled; enter SARS-CoV-2 sterile injectables...
Wow… some interesting stuff.
—-
WARNING: CYTOKINE RELEASE SYNDROME, NEUROLOGICAL TOXICITIES, and SECONDARY HEMATOLOGICAL MALIGNANCIES
• Cytokine Release Syndrome (CRS), including fatal or life-threatening reactions, occurred in patients receiving KYMRIAH. Do not administer KYMRIAH to patients with active infection or inflammatory disorders. Treat severe or life-threatening CRS with tocilizumab or tocilizumab and corticosteroids [see Dosage and Administration (2.3, 2.4), Warnings and Precautions (5.1)].
• Neurological toxicities, which may be severe or life-threatening, can occur following treatment with KYMRIAH, including concurrently with CRS. Monitor for neurological events after treatment with KYMRIAH. Provide supportive care as needed [see Warnings and Precautions (5.2)].
• T cell malignancies have occurred following treatment of hematologic malignancies with BCMA- and CD19- directed genetically modified autologous T cell immunotherapies, including KYMRIAH [see Warnings and Precautions (5.9)].
• KYMRIAH is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the KYMRIAH REMS [see Warnings and Precautions (5.3)].
—-
It looks like the idea is to target the CD19 glycoprotein/receptor/co-receptor using modified T-Cells (CD8+’s?) to wipe out the population of B-cells (naive, memory, plasma) that express it. The main idea is that the CD19 receptor is highly specific to “cancerous” B-cells (lymphoma). Yet CD19 seems to actually play a role in B-Cell activation.
Seems like this strategy is akin to saying that inflammation is bad for you. Let’s kill all the cells that look inflamed.
It doesn’t seem like they have any appreciation for the complex signaling and orchestration that all these immune system cells do to keep everything from collapsing.
Anyhow, it’s interesting how all these biologics is basically supported by a number of key technology platforms that make them a bit interchangeable.
Regarding mABs, they are probably a much simpler therapeutic if one thinks about it. The “base” (and probably wrong) understanding is that ABs are a simple flagging mechanism for the immune system which will then target the attached organic. To make it extra good, they also target RBDs (Receptor Binding Domains) so that even if the immune system doesn’t do it’s job, it at least “blocks” the effect of the target organic.
Yet, when you look into well established mABs like Solensia(cats)/Librela(dogs) which target the NGF (nerve growth factor) and many groups popping up with names like “Solensia killed my cat”, it’s clear they don’t even know how ABs work in the system. Yet, hubris is going to lead them to believe they can inject even more complicated biologics into an incredibly complex system they barely understand have it "work”. 🤞🤞
I think your comment regarding everyone knowing about pharma's carrying on's is wrong, I certainly had no idea until the last few years and majority still have no idea, as they wave me away with my conspiracy facts! Hedley, I've been searching through your articles, with no luck, for the one that mentions the "international regulatory body" that advises individual regulatory bodies. Can you provide link please? Thanks.
I should also say, Markker, that it is really heartening to know you are trying to influence the unbelievers - softly, softly catchee monkey...:O)
This is it, Markker: https://www.ich.org/
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) is unique in bringing together the regulatory authorities and pharmaceutical industry to discuss scientific and technical aspects of pharmaceuticals and develop ICH guidelines. Since its inception in 1990, ICH has gradually evolved, to respond to increasingly global developments in the pharmaceutical sector and these ICH guidelines are applied by a growing number of regulatory authorities. ICH's mission is to achieve greater harmonisation worldwide to ensure that safe, effective and high quality medicines are developed, and registered and maintained in the most resource efficient manner whilst meeting high standards. Since its announcement of organisational changes in October 2015, ICH has grown as an organisation and now includes 23 Members and 35 Observers."
This is an NGO set up by WHO/Bill Gates in 2012: https://www.icmra.info/drupal/en/aboutus/icmra_chair Note the 1st Chair was CEO of MHRA,, who became a Gates Foundation employee in 2019, and the current chair Ms Emer Cooke, former WHO, now executive director of the European Medicines Agency!!!
Thanks. On Jonathan Engler's stack, he is looking to find out more on an international association of medical regulatory agencies. Look here sanityunleashed.substack.com/p/who-funds-controls-this-shadowy-umbrella Are they related/same? I watched the video a long time ago and wondered if anyone looking into it.
From what I can see, the IAMRA is different to the ICMRA. In terms for facilitating COVID, I'd say the ICMRA is the one with its tentacles around all the global, country based authorities. Take a look at the membership: https://www.icmra.info/drupal/en/aboutus/participatingregulatoryauthorities - ICMRA is duplicating the work of ICH, which was formally set up to be a global harmonization vehicle,
The ich.org has press release for June 2024 in Japan. Additional agenda item is Assessment and control of DNA Reactive (Mutagenic) impurities in pharmaceuticals to limit potential carcenogenic risk" horse - stable - door - bolted, springs to mind.
Yes, and ICH was almost certainly infiltrated by the Gates/Who machine some time leading up to COVID, probably well before...
"100 days"... not to the market in that time unless there is government collusion and looking the other way, kickbacks and illegal activity.
That was Melinda Gates and UK Government plan: Government and life science industry join forces on 100 Days Mission for future pandemics https://www.gov.uk/government/news/government-and-life-science-industry-join-forces-on-100-days-mission-for-future-pandemics
UK Government is right at the heart of the scam, to put UK number 1 in the world of life sciences...
The new frightening introductory phrase: "Trust me. I'm from Pharma". Thanks as always Hedley for the Heads Up.
fantastic; so much to take in; the world getting ripped off ...
Have you seen this?
https://lionessofjudah.substack.com/p/edward-dowd-global-vaccine-impact?publication_id=581065&utm_campaign=email-post-title&r=18rzag&utm_medium=email